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September 10, 2025AntibioticsOpen Access

Bactericidal Activities of Nanoemulsion Containing Piper betle L. Leaf and Hydroxychavicol Against Avian Pathogenic Escherichia coli and Modelling Simulation of Hydroxychavicol Against Bacterial Cell Division Proteins

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Authors

KRKunchaphorn RatchasongPSPhirabhat SaengsawangGYGorawit Yusakul

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Overview

In vitro analysis shows potent bactericidal activity of nanoemulsion and hydroxychavicol against APEC, suggesting new antibacterial strategies.

Key Points

  • The nanoemulsion and hydroxychavicol exhibit significant antibacterial effects against APEC.
  • Minimum inhibitory concentration (MIC) values for the nanoemulsion were 0.06–0.25% v/v, showing strong bactericidal potential.
  • Molecular dynamics simulations demonstrated hydroxychavicol's high affinity for key bacterial cell division proteins, indicating potential mechanisms of action.
  • These findings suggest that NEPE and hydroxychavicol may serve as effective alternatives to combat multidrug-resistant APEC infections.

Cite This Study

Ratchasong et al. (2025) studied this question.

synapsesocial.com/papers/68c1b82654b1d3bfb60eca5bhttps://doi.org/10.3390/antibiotics14080788
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deep Eutectic Solvent-Based Emulsion Containing Piper betle L. Extract and Hydroxychavicol Prevent Biofilm Development and Surface Adhesion of Avian Pathogenic Escherichia coli on Stored Chicken Meat2026
  2. 2Exploration of the Antibacterial Mechanism of the Aqueous Extract of Bidens pilosa L. Against the Avian Pathogen Escherichia coli2025
  3. 3Evaluation of Probiotic Metabolites Mediated Antimicrobial Activity and Inhibition of Virulence Factors in Avian Pathogenic Escherichia Coli2026
  4. 4Effect of Medicinal Plant Extracts on Biofilm Formation in <i>Escherichia Coli</i> Strains Causing Avian Colibacillosis2025
  5. 5The <i>in vitro</i> Antimicrobial Effects of Hydrolysable and Condensed Tannin Extracts on <i>Escherichia coli</i> Isolated from Pathological Samples of Deceased Poultry2024