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Different Fasting Methods Combined With Running Exercise Regulate Glucose Metabolism via AMPK/SIRT1/BDNF Pathway in Mice

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Time-restricted fasting significantly enhances glucose metabolism compared to alternate-day fasting.
Running exercise increases muscle glycogen content and improves blood glucose regulation in mice after 6 weeks.
Increased expression of AMPK, SIRT1, and BDNF proteins indicates activated glucose-lipid metabolism pathways.
Fasting combined with exercise outperforms mono-fasting methods in regulating glucose uptake in normal mice.

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Randomized trial shows that time-restricted fasting improves glucose metabolism in mice, highlighting AMPK and BDNF pathways.

Wang et al. (2025) studied this question.

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