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September 10, 2025Open Access

A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs

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Authors

PRPablo Ruíz-AmezcuaMHM. HernandezJFJavier E. Flores

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Overview

Single-nucleus RNA sequencing profiles reveal distinct neuronal subtypes in the mouse spinal cord, suggesting roles for non-coding RNAs.

Key Points

  • Non-coding RNAs enhance the resolution of neuronal subtypes in the mouse lumbar spinal cord.
  • Differential expression analysis highlights lineage-associated non-coding RNAs in various spinal cord populations.
  • Single-nucleus RNA sequencing analysis comprises over 86,000 nuclei, revealing 17 distinct neuronal subtypes.
  • This atlas serves as a reference for studying spinal plasticity, injury, and regeneration in the lumbar spinal cord.

Cite This Study

Ruíz-Amezcua et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb6354b1d3bfb60ecff5https://doi.org/10.20944/preprints202508.0084.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs2025
  2. 2A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences2025 · 1 citations
  3. 3Conserved Cell Type Signatures Across the Brainstem and Spinal Cord in the Mouse Central Nervous System2026
  4. 4Characterizing the molecular and cellular biology of healthy adult human spinal cord2026
  5. 5Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord2024 · 19 citations