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September 10, 2025BioTechOpen Access

A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs

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Authors

PRPablo Ruiz-AmezcuaUniversidad de JaénMHM. HernandezServicio de Salud de Castilla La ManchaJFJavier E. FloresPacific Northwest National Laboratory

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Implication

Integrative RNA sequencing reveals distinct neuronal subtypes in lumbar spinal cord, highlighting roles of non-coding RNAs.

Key Points

  • Non-coding RNAs contribute to unique signatures in spinal cell types, indicating their functional importance.
  • The analysis involved over 86,000 nuclei from 16 samples, establishing a comprehensive reference.
  • A high-resolution transcriptomic atlas was created using single-nucleus RNA sequencing methods.
  • Findings may advance understanding of spinal plasticity, injury response, and regeneration.

Cite This Study

Ruiz-Amezcua et al. (2025) studied this question.

synapsesocial.com/papers/68c187179b7b07f3a0610af6https://doi.org/10.3390/biotech14030070
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