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Comparison of Hypertonic Saline with Normal Saline Nebulization in the Management of Bronchiolitis in Children

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Hypertonic saline nebulization leads to greater improvement in clinical severity score compared to normal saline.
Median change in clinical severity score after 120 minutes was 3.00 with hypertonic saline versus 2.00 with normal saline.
Significant results were observed after 30, 60, and 120 minutes, with a p-value less than 0.05.
The study analyzed data from sixty infants enrolled in a randomized controlled trial.

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Randomized controlled trial shows hypertonic saline reduces clinical severity score in bronchiolitis better than normal saline.

Riaz et al. (2025) studied this question.

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