What does this research mean for the field?

Inhaled hypertonic saline does not reduce the length of hospital stay or improve clinical severity scores in children hospitalized with acute bronchiolitis compared to normal saline, though it is associated with a lower risk of rehospitalization. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to evaluate the effectiveness of nebulised hypertonic saline in reducing hospital length of stay for children diagnosed with bronchiolitis.

June 6, 2026Acta Paediatrica

Randomised, Multicentre Clinical Trial Found That Hypertonic Saline Did Not Reduce the Length of Stay of Hospitalised Patients With Acute Bronchiolitis

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This research aims to evaluate the effectiveness of nebulised hypertonic saline in reducing hospital length of stay for children diagnosed with bronchiolitis.
Randomized double-blind trial conducted in four Polish paediatric units from October 2023 to April 2025.
181 hospitalized infants aged 5 weeks to 24 months were randomly assigned to receive either nebulised 3% hypertonic saline or 0.9% normal saline until discharge.
Clinical outcomes were followed for 7 days post-treatment.
Median hospital stay was 2.68 days for hypertonic saline and 2.79 days for normal saline, with a mean difference of -0.11 days (95% CI -0.73 to 0.12, p = 0.3).
No significant differences in clinical severity scores were observed between both treatment groups.
Readmissions occurred only in the normal saline group at a rate of 5.9%.

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Implication

Randomized trial compares nebulised hypertonic saline and normal saline in hospitalized infants, showing no difference in length of stay and severity scores.

Cite This Study

Szupieńko-Bujak et al. (2026) studied this question.

synapsesocial.com/papers/6a23bafd71a5da9775e7695d https://doi.org/10.1111/apa.70632

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Implication

Randomized trial compares nebulised hypertonic saline and normal saline in hospitalized infants, showing no difference in length of stay and severity scores.

Randomised, Multicentre Clinical Trial Found That Hypertonic Saline Did Not Reduce the Length of Stay of Hospitalised Patients With Acute Bronchiolitis

Key Points

Discussion

Implication

Cite This Study

Randomised, Multicentre Clinical Trial Found That Hypertonic Saline Did Not Reduce the Length of Stay of Hospitalised Patients With Acute Bronchiolitis

Key Points

Discussion

Implication

Cite This Study

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