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September 10, 2025GenesOpen Access

A Genetically-Informed Network Model of Myelodysplastic Syndrome: From Splicing Aberrations to Therapeutic Vulnerabilities

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Authors

SYSanghyeon YuJKJunghyun KimMKMan S. Kim

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Overview

Review synthesizes mechanisms behind myelodysplastic syndrome, revealing splicing and epitranscriptomic factors influencing treatment outcomes.

Key Points

  • Myelodysplastic syndrome patients show varied responses to therapies, with some responding well while others fail treatment.
  • Four mechanisms drive MDS pathology: genetic alterations, aberrant stem cell architecture, dysregulated epitranscriptomics, and microenvironment changes.
  • Analyzing single-cell technologies reveals important insights about splicing aberrations and their impact on treatment response.
  • Understanding these mechanisms can help transition toward precision medicine, improving therapeutic strategies for MDS patients.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68c1bb7054b1d3bfb60ed7aahttps://doi.org/10.3390/genes16080928
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone marrow microenvironment reprogramming in myelodysplastic neoplasms: from pathological mechanisms to targeted therapeutic strategies2026
  2. 2Treatment of myelodysplastic syndromes in the era of precision medicine and immunomodulatory drugs: a focus on higher-risk disease2022 · 14 citations
  3. 3Advances and Challenges in the Management of Myelodysplastic Syndromes2025 · 6 citations
  4. 4Multicohort transcriptomic integration and machine learning-based diagnostic modeling for myelodysplastic syndromes2026
  5. 5Myelodysplastic Neoplasms (MDS): The Current and Future Treatment Landscape2024 · 8 citations