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Verification of Pathologic ECV Estimated with Clinical T1 Mapping Methods Using an Isotope-based Reference

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Animal study verifies T1 mapping accuracy for extracellular volume in ischemic myocardium, indicating clinical reliability.

High correlation was found between T1 mapping and SPECT measured ECV, demonstrating reliability in ischemia evaluation.
The MOLLI sequences overestimated ECV in infarct regions, with bias range of 4.9% to 8.2%, indicating potential limitations.
Multiple imaging sequences were evaluated, highlighting variations in estimating ECV in remote myocardial regions post-ischemia.
Accurate ECV measurement is crucial for clinical decision-making in cardiac ischemia and related conditions.

Nordlund et al. (2025) studied this question.

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