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TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin

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Pharmacological TRPA1 activation reduces inflammatory gene expression in psoriatic skin, suggesting potential treatment pathways.

TRPA1 activation significantly down-regulates inflammatory gene expression in both normal and psoriatic skin, impacting treatment strategies.
Notable gene changes were observed; in healthy skin, TRPA1 activation decreased inflammation-related genes linked to interferon signaling.
In lesional psoriatic skin, specific cytokine signaling genes were reduced after TRPA1 agonist treatment, highlighting its modulatory role.
DMSO treatment was linked to increased expression of inflammatory genes, but this was normalized during subsequent analysis.

Kemény et al. (2025) studied this question.

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