What question did this study set out to answer?

The aim is to investigate the role of TRPA1 in keratinocytes and its effects on cellular functions in response to inflammation.

January 22, 2026CellsOpen Access

TRPA1 as a Key Regulator of Keratinocyte Homeostasis and Inflammation in Human Skin

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Exploration of TRPA1's role reveals its impact on immune activation and keratinocyte proliferation, suggesting implications for skin health.

The aim is to investigate the role of TRPA1 in keratinocytes and its effects on cellular functions in response to inflammation.
Evaluated TRPA1 expression in human keratinocytes.
Activated TRPA1 with the agonist allyl isothiocyanate (AITC).
Measured cellular proliferation, immune activation, and neuropeptide release.
Assessed the effects of pro-inflammatory cytokines on TRPA1 function.
TRPA1 was expressed in basal keratinocytes and upregulated by pro-inflammatory cytokines.
AITC induced a rapid calcium influx and reduced keratinocyte proliferation.
TRPA1 activation downregulated surface expression of HLA-DR and ICAM-1.
mRNA levels of inflammatory markers (CXCL10, CXCL8, CCL5, CCL20) decreased with TRPA1 activation.

Cattani et al. (2026) studied this question.

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Exploration of TRPA1's role reveals its impact on immune activation and keratinocyte proliferation, suggesting implications for skin health.