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September 10, 2025Alzheimer s & DementiaOpen Access

Enhancing the validity of CAIDE dementia risk scores with resting heart rate and machine learning: An analysis from the National Alzheimer's Coordinating Center across all races/ethnicities

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Authors

SAShakiru A. AlakaSNSoFong Cam NganMSMostafa Shookoni

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Overview

Analysis shows improved predictive accuracy for dementia risk in diverse populations, highlighting ethnic differences.

Key Points

  • Incorporating resting heart rate significantly improves dementia risk prediction accuracy.
  • Model performance improvements were observed across multiple racial groups, with AUC ranging from 0.80 to 0.91.
  • Random forest algorithm applied in the National Alzheimer's Coordinating Center dataset enables complex variable relationship capture.
  • Findings emphasize the need for tailored dementia risk models for better applicability across diverse races.

Cite This Study

Alaka et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd2a54b1d3bfb60edf1ahttps://doi.org/10.1002/alz.70442
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cognition and the Predictive Utility of Three Risk Scores in an Ethnically Diverse Sample2020 · 17 citations
  2. 2Resting Heart Rate and Cognitive Decline: A Meta-Analysis of Prospective Cohort Studies2022 · 13 citations
  3. 3Resting heart rate, cognitive function, and inflammation in older adults: a population-based study2023 · 10 citations
  4. 4Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations2024 · 44 citations
  5. 5The National Alzheimer's Coordinating Center (NACC) Database: The Uniform Data Set2007 · 950 citations