May 10, 2021Työväentutkimus VuosikirjaOpen Access

Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis

Q: What is the clinical evidence from this study?

Study design: RCT. Population: At-risk older adults (n=112). Intervention: Multidomain lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) vs. General health advice. Primary outcome: Change in hippocampus volume associated with reduction in CAIDE score (interaction β coefficient -0.40, p=0.02).

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Key result

A reduction in CAIDE score during a 2-year multidomain lifestyle intervention was associated with less decline in hippocampus volume compared to control (interaction β = -0.40, p = 0.02).

Why the study?

Does a multidomain lifestyle intervention improve neuroimaging biomarkers in at-risk older adults who successfully reduce their CAIDE dementia risk score?

Population

112 at-risk older adults, aged 60-77 years, from the general population with repeated brain MRI measures

Comparison

Multidomain intervention for 2 years vs Control group receiving general health advice…

Design

RCT, Randomized to either multidomain intervention or control group

Follow-up

2 years

Authors

RSRuth Anna Stephen TNTiia Ngandu YLYawu Liu

Discussion

Member takes

Overview

May preserve hippocampal volume via successful CAIDE reduction; extends RCT evidence for multidomain lifestyle effects on neuroimaging biomarkers.

Study Design

Type

RCT (n=112)

Randomization

randomized

Structured PICO

Does a multidomain lifestyle intervention improve neuroimaging biomarkers in at-risk older adults who successfully reduce their CAIDE dementia risk score?

Population

112 at-risk older adults aged 60-77 years from the general population with repeated brain MRI measures followed for 2 years.

Intervention

Multidomain intervention (diet, exercise, cognitive training, and vascular risk management) for 2 years

Comparator

Control group receiving general health advice for 2 years

Outcome

Associations between change in CAIDE score and change in neuroimaging biomarkers (brain MRI measures including hippocampal, total gray matter, and white matter lesion volumes, and Alzheimer's disease signature cortical thickness; and PiB-PET measures) at 2 yearssurrogate

Main Result

Effect estimate: interaction β coefficient -0.40

p-value: p=0.02

A multidomain lifestyle intervention may help preserve hippocampal volume in at-risk older adults who successfully reduce their overall cardiovascular and dementia risk profile.

Limitations

Exploratory finding requires further testing and validation in larger studies
Exploratory post-hoc finding
Requires further testing and validation in larger studies
Small sample size for imaging subgroups

Cite This Study

Stephen et al. (2021) conducted an RCT in At-risk older adults (n=112). Multidomain lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) vs. General health advice was evaluated on Change in hippocampus volume associated with reduction in CAIDE score (interaction β coefficient -0.40, p=0.02). A reduction in CAIDE score during a 2-year multidomain lifestyle intervention was associated with less decline in hippocampus volume compared to control (interaction β = -0.40, p = 0.02).

synapsesocial.com/papers/6ab32987f075177e3bb39b27 https://doi.org/10.1093/gerona/glab130

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May 10, 2021Työväentutkimus VuosikirjaOpen Access

Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis

View Full Paper

Ask AI

Bookmark

Key result

A reduction in CAIDE score during a 2-year multidomain lifestyle intervention was associated with less decline in hippocampus volume compared to control (interaction β = -0.40, p = 0.02).

Why the study?

Does a multidomain lifestyle intervention improve neuroimaging biomarkers in at-risk older adults who successfully reduce their CAIDE dementia risk score?

Population

112 at-risk older adults, aged 60-77 years, from the general population with repeated brain MRI measures

Comparison

Multidomain intervention for 2 years vs Control group receiving general health advice…

Design

RCT, Randomized to either multidomain intervention or control group

Follow-up

2 years

Authors

RSRuth Anna Stephen TNTiia Ngandu YLYawu Liu

Discussion

Member takes

Overview

May preserve hippocampal volume via successful CAIDE reduction; extends RCT evidence for multidomain lifestyle effects on neuroimaging biomarkers.

Study Design

Type

RCT (n=112)

Randomization

randomized

Structured PICO

Does a multidomain lifestyle intervention improve neuroimaging biomarkers in at-risk older adults who successfully reduce their CAIDE dementia risk score?

Population

112 at-risk older adults aged 60-77 years from the general population with repeated brain MRI measures followed for 2 years.

Intervention

Multidomain intervention (diet, exercise, cognitive training, and vascular risk management) for 2 years

Comparator

Control group receiving general health advice for 2 years

Outcome

Main Result

Effect estimate: interaction β coefficient -0.40

p-value: p=0.02

A multidomain lifestyle intervention may help preserve hippocampal volume in at-risk older adults who successfully reduce their overall cardiovascular and dementia risk profile.

Limitations

Exploratory finding requires further testing and validation in larger studies
Exploratory post-hoc finding
Requires further testing and validation in larger studies
Small sample size for imaging subgroups

Cite This Study

synapsesocial.com/papers/6ab32987f075177e3bb39b27 https://doi.org/10.1093/gerona/glab130

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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