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September 10, 2025Brain

Alzheimer and cardiovascular genetic scores and cognition: the FINGER randomized controlled trial

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Authors

GSGazi SaadmaanCDCarolina DalmassoMMMaleeha Maria

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Overview

Randomized controlled trial assessed cognitive changes related to genetic risk scores in at-risk older adults, suggesting lifestyle interventions may help.

Key Points

  • Cognition improved in higher-risk females with genetic susceptibility for Alzheimer's disease.
  • The FINGER trial showed a significant intervention-control difference of 0.045 for higher-risk females.
  • Findings suggest multidomain lifestyle interventions can benefit individuals with Alzheimer's and cardiovascular genetic risks.
  • Gender differences were noted for genetic risk scores related to Alzheimer's disease within the intervention.

Cite This Study

Saadmaan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a90554b1d3bfb60e1dd7https://doi.org/10.1093/brain/awaf277
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Statistics in Medicine — Reporting of Subgroup Analyses in Clinical Trials2007 · 1,455 citations
  2. 2Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial2022 · 90 citations
  3. 3Japan‐Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial2024 · 98 citations
  4. 4Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured by Positron Emission Tomography in Clinically Normal Older Adults2019 · 393 citations
  5. 5Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study2001 · 1,625 citations