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September 10, 2025Nature CommunicationsOpen Access

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

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CV2/CRMP5 autoantibodies induce neuropathic pain by binding to neurons in the spinal cord.
Rats immunized with a DNA vaccine for CRMP5 exhibit increased neuronal excitability and pain sensitivity.
Therapeutic treatment with anti-CD20 depleting B cells improves autoimmunity and pain symptoms.
These findings reveal key mechanisms in paraneoplastic neurological syndromes, highlighting potential therapeutic targets.

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This study demonstrates how CV2/CRMP5 autoantibodies enhance pain in rats, suggesting a target for treatment of autoimmune neuropathy.

Martin et al. (2025) studied this question.

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