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Protective Effects of MK‐801 on Apoptosis in Immature Rats With Traumatic Brain Injury

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Experimental analysis reveals MK-801 decreased apoptosis markers in the hippocampus, suggesting a protective role in TBI.

MK-801 treatment significantly reduces apoptosis in the hippocampus following traumatic brain injury.
The study observed marked reductions in BAX and caspase-3 immunoreactivities in the MK-801 group compared to the TBI group.
Forty-two immature rats were utilized, showing different apoptotic responses across treatment conditions.
These findings highlight MK-801's potential neuroprotective effect in managing consequences of traumatic brain injury.

Çiğel et al. (2025) studied this question.

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