What question did this study set out to answer?

To evaluate the neuroprotective efficacy of the NMDA receptor antagonist MK-801 administered before and after a hypoxic-ischemic insult in a neonatal rat model.

May 1, 1989Neurology

Posthypoxic treatment with MK‐801 reduces hypoxic‐ischemic damage in the neonatal rat

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Authors

HHH. HattoriCarnegie Mellon University AMAlexandre MorinUniversity of Ottawa PSPhillip H. SchwartzChildren's Hospital of Orange County

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Implication

Animal study demonstrates MK-801 reduces cerebral infarction when administered up to one hour post-insult in neonatal rats, indicating a viable therapeutic window for hypoxic-ischemic injury.

Key Points

To evaluate the neuroprotective efficacy of the NMDA receptor antagonist MK-801 administered before and after a hypoxic-ischemic insult in a neonatal rat model.
Seven-day-old rats underwent bilateral carotid artery ligation followed by exposure to 8% oxygen for 1 hour.
Animals received intraperitoneal MK-801 (10 mg/kg) either 0.5 hours before, immediately after, or 1 hour after hypoxia.
Brain damage in the cerebral cortex, striatum, and hippocampus was evaluated histologically 72 hours post-injury.
Pretreatment with MK-801 completely prevented cerebral cortex infarction, while treatment immediately and 1 hour post-hypoxia reduced infarcted area by 76% and 52%, respectively.
Administration of MK-801 0.5 hours before and immediately after hypoxia reduced striatal damage.
Pretreatment 0.5 hours prior to the insult attenuated neuronal necrosis in hippocampal regions.

Cite This Study

Hattori et al. (1989) studied this question.

synapsesocial.com/papers/69e931fa5eea8a07da94b739 https://doi.org/10.1212/wnl.39.5.713

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Implication

Animal study demonstrates MK-801 reduces cerebral infarction when administered up to one hour post-insult in neonatal rats, indicating a viable therapeutic window for hypoxic-ischemic injury.

Posthypoxic treatment with MK‐801 reduces hypoxic‐ischemic damage in the neonatal rat

Discussion

Member takes

Implication

Key Points

Cite This Study

Posthypoxic treatment with MK‐801 reduces hypoxic‐ischemic damage in the neonatal rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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