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September 10, 2025Nature CommunicationsOpen Access

Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents

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Authors

ZZZhongyu ZhangZZZhengde ZhaoXHXiuyi Huang

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Overview

Experimental findings demonstrate that galectin-3 improves angiogenesis and wound healing in diabetes, highlighting the role of integrin α5β1 and AGEs.

Key Points

  • Galectin-3 treatment improved diabetic wound healing in rodents, restoring its function disrupted by advanced glycation end-products.
  • Diabetic conditions with accumulated AGEs impaired galectin-3's interaction with integrin α5β1, crucial for angiogenesis.
  • The research utilized a pre-clinical rodent model to analyze the effects of galectin-3 on wound healing and angiogenic signaling.
  • Findings support local galectin-3 therapy as a potential strategy for managing diabetic foot ulcers, emphasizing its implications for treatment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd2a54b1d3bfb60ee0f3https://doi.org/10.1038/s41467-025-62320-w
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