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August 16, 2026GelsOpen Access

AB4-Loaded Nanomicelle Hydrogel Promotes Targeting of the Dysregulated Diabetic Wound Microenvironment via Coordinated Multistage Repair

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Authors

XSXue ShaoDMDe-Jing MaYZYa-Ni Zhang

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Overview

Preclinical study demonstrates accelerated diabetic wound healing using a multifunctional nanomicelle hydrogel in diabetic mice, indicating a promising multistage therapeutic approach.

Key Points

  • Develop and evaluate a multifunctional drug-carrier integrated nanocomposite hydrogel loaded with Anemoside B4 to target multiple stages of dysregulated diabetic wound healing.
  • Synthesized amphiphilic PNO-GA nanomicelles loaded with Anemoside B4 (PGAs) and embedded them into a carboxymethyl chitosan-dopamine-vanillin (CDV) hydrogel matrix.
  • Assessed antioxidant capacity, cell migration, angiogenesis, and macrophage polarization in vitro.
  • Evaluated wound closure rates, tissue remodeling, and molecular pathways (NF-κB and PI3K/AKT/HIF-1α) in a streptozotocin-induced diabetic mouse model compared to control, CDV, PNO@CDV, and AB4@CDV.
  • PGAs@CDV accelerated wound closure, promoted faster hemostasis, enhanced collagen deposition, and increased blood vessel formation relative to all control and single-component groups in diabetic mice.
  • In vitro evaluations showed enhanced cell migration, antioxidant activity, and promoted M1-to-M2 macrophage polarization.
  • Mechanistic analyses revealed significant suppression of inflammatory NF-κB signaling alongside activation of the pro-angiogenic PI3K/AKT/HIF-1α pathway.

Cite This Study

Shao et al. (2026) studied this question.

synapsesocial.com/papers/6a8179bcf2fb91fc834acfdfhttps://doi.org/10.3390/gels12080722
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Tissue‐Homologous Keratin‐PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment‐Adaptive Repair of Chronic Diabetic Wounds2026
  2. 2Multi-functional phytoglycogen-derived hydrogel dressings promote the fast closure of diabetic wound in vitro and in vivo2025
  3. 3Multi-functional phytoglycogen-derived hydrogel dressings promote the fast closure of diabetic wound in vitro and in vivo2026 · 1 citations
  4. 4An Adhesive Multifunctional Hydrogel for Sequential Anti-inflammatory, Antioxidant, and Pro-regenerative Diabetic Wound Therapy2026
  5. 5Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing2026