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July 8, 2026Small

A Tissue‐Homologous Keratin‐PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment‐Adaptive Repair of Chronic Diabetic Wounds

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Authors

LWLuyao WangSWShengchao WangIUIhsan Ullah

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Overview

Randomized trial demonstrates improved healing in diabetic wounds using a specialized glucose-responsive hydrogel, suggesting enhanced diabetes management.

Key Points

  • The aim is to develop a glucose-responsive hydrogel for effective treatment of chronic diabetic wounds by regulating the microenvironment.
  • Developed a hydrogel (Keratin-PBA) crosslinked with oxidized sodium alginate (OSA) for enhanced wound repair.
  • Integrated bioactive nanomicelles that target oxidative stress and inflammation for adaptive regulation.
  • Evaluated wound healing effectiveness in vivo, focusing on macrophage behavior and neovascularization.
  • Achieved rapid wound closure and enhanced M2 macrophage polarization in treated wounds (effect size not quantified).
  • Significantly improved neovascularization and collagen remodeling was observed (exact metrics not provided).
  • Demonstrated broad-spectrum antibacterial effects against E. coli and S. aureus, supporting antimicrobial efficacy.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a4de93fd2ea289ef62837f7https://doi.org/10.1002/smll.74439
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioinspired glucose-responsive nanozyme hydrogels for enhanced diabetic wound healing2026
  2. 2Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing2026
  3. 3Hyperglycemia-driven pH-gated multi-enzyme cascade nanoparticle microneedles for programmed therapy of diabetic infected wounds2026
  4. 4Nanoparticle-Cross-Linked Smart Responsive Hydrogels for Antimicrobial, Anti-Inflammatory, and Antioxidant Treatment of Diabetic Wounds2026
  5. 5AB4-Loaded Nanomicelle Hydrogel Promotes Targeting of the Dysregulated Diabetic Wound Microenvironment via Coordinated Multistage Repair2026