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June 6, 2026Biomacromolecules

Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing

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Authors

HWHanzhang WangBLBo LuJZJie Zhou

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Overview

Randomized trial demonstrates improved wound healing in diabetic models with a pH/glucose responsive hydrogel, suggesting effective treatment options.

Key Points

  • The study aims to develop a hydrogel that can respond to pH and glucose levels for treating diabetic wounds.
  • Constructed a hydrogel network using Schiff base bonding, metal-polyphenol complexation, and hydrogen bonding.
  • Tested in a full-thickness diabetic rat wound model for efficacy on wound healing.
  • Analyzed the release mechanism of nitric oxide and its effects on tissue regeneration.
  • Wound closure was significantly accelerated, promoting epithelial regeneration and collagen deposition.
  • The hydrogel resulted in enhanced neovascularization compared to controls.
  • Demonstrated antibacterial, anti-inflammatory, antioxidative, and proangiogenic effects in vitro.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb2071a5da9775e76b5fhttps://doi.org/10.1021/acs.biomac.6c00725
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolically Programmed Biomass Hydrogel for Phase‐Transition Therapy of Chronic Diabetic Wounds2025
  2. 2Bioinspired glucose-responsive nanozyme hydrogels for enhanced diabetic wound healing2026
  3. 3A Tissue‐Homologous Keratin‐PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment‐Adaptive Repair of Chronic Diabetic Wounds2026
  4. 4Advances in the Application of Responsive Hydrogels for Diabetic Wound Therapy2026
  5. 5An Adhesive Multifunctional Hydrogel for Sequential Anti-inflammatory, Antioxidant, and Pro-regenerative Diabetic Wound Therapy2026