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June 6, 2026Biomacromolecules

Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing

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Authors

HWHanzhang WangBLBo LuJZJie Zhou

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Overview

Randomized trial demonstrates improved wound healing in diabetic models with a pH/glucose responsive hydrogel, suggesting effective treatment options.

Key Points

  • The study aims to develop a hydrogel that can respond to pH and glucose levels for treating diabetic wounds.
  • Constructed a hydrogel network using Schiff base bonding, metal-polyphenol complexation, and hydrogen bonding.
  • Tested in a full-thickness diabetic rat wound model for efficacy on wound healing.
  • Analyzed the release mechanism of nitric oxide and its effects on tissue regeneration.
  • Wound closure was significantly accelerated, promoting epithelial regeneration and collagen deposition.
  • The hydrogel resulted in enhanced neovascularization compared to controls.
  • Demonstrated antibacterial, anti-inflammatory, antioxidative, and proangiogenic effects in vitro.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb2071a5da9775e76b5fhttps://doi.org/10.1021/acs.biomac.6c00725
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