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June 11, 2026Materials & DesignOpen Access

Bioinspired glucose-responsive nanozyme hydrogels for enhanced diabetic wound healing

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Authors

RHRenying HeChongqing Emergency Medical CenterYYYanlin YuArmy Medical UniversitySXSihong XueArmy Medical University

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Implication

Randomized trial shows enhanced wound healing in diabetic models, indicating improved glucose management and tissue recovery.

Key Points

  • This research aims to develop an innovative hydrogel that responds to glucose levels to improve diabetic wound healing.
  • Developed a glucose-responsive nanozyme hydrogel composed of PLGA nanoparticles and modified chitosan and hyaluronic acid.
  • Conducted in vitro tests measuring toxicity, fibroblast migration, and inflammation levels.
  • Evaluated wound healing in diabetic mice over 14 days, comparing the hydrogel's effectiveness to non-responsive controls.
  • Achieved 95.67% wound closure by day 14 in diabetic mice, outperforming controls and commercial growth factors.
  • Eliminated over 90% of reactive oxygen species and doubled fibroblast migration in vitro.
  • Activated the PI3K-Akt pathway while suppressing IL-17 signaling.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/6a2a503380c8f91e7f39cd32https://doi.org/10.1016/j.matdes.2026.116365
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hydrogel-Based Treatment of Diabetic Wounds: From Smart Responsive to Smart Monitoring2025 · 33 citations
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  4. 4The IL-17 family in diseases: from bench to bedside2023 · 462 citations
  5. 5Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective2023 · 274 citations