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November 17, 2025Advanced Functional Materials

Metabolically Programmed Biomass Hydrogel for Phase‐Transition Therapy of Chronic Diabetic Wounds

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Authors

YZYifei ZhaoHCHaoxin CaiXRXiangke Rong

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Overview

Innovative hydrogel demonstrates antimicrobial activity and promotes tissue regeneration in chronic diabetic wounds, suggesting potential for improved healing.

Key Points

  • The aim is to develop a hydrogel that manages chronic diabetic wounds by regulating reactive oxygen species (ROS) and promoting healing.
  • Engineered a hydrogel that dynamically regulates ROS via phase-transition therapy.
  • Synthesized H2S donor attached to oxidized dextran and integrated it with glucose oxidase (GOx) in carboxymethyl cellulose.
  • Evaluated hydrogel properties including tissue adhesion, mechanical resilience, and self-healing capabilities.
  • GOx-generated ROS eliminated 98% of methicillin-resistant Staphylococcus aureus in 4 hours.
  • Hydrogel facilitated M2 macrophage polarization and angiogenesis.
  • Achieved over 90% recovery in self-healing within 30 minutes.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/692509eec0ce034ddc352a42https://doi.org/10.1002/adfm.202509318
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Programming the Diabetic‐Infected Wound Microenvironment With a Smart Hydrogel for Ordered Healing Cascade Restoration2026
  2. 2Glucose/ROS/pH Triple Editing “Domino Hydrogel” Accelerates Diabetic Wound Healing via Hypoglycemic, Antioxidant, Antibacterial, and Macrophage Polarization2024 · 20 citations
  3. 3Dynamic Biomass-Based Hydrogel with Dual pH/Glucose Responsiveness for Controlled Nitric Oxide Release and Diabetic Wound Healing2026
  4. 4Self‐Evolving Hydrogel Dressing Temporally Accelerates Infected Diabetic Wound Healing2026 · 5 citations
  5. 5Hydrogel‐Based ROS‐Regulating Strategy: Reprogramming the Oxidative Stress Imbalance in Advanced Diabetic Wound Repair2025 · 87 citations