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September 2, 2026Advanced Healthcare MaterialsOpen Access

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

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Authors

LWLele WuNanjing Medical UniversityXHXuetong HaoYZYang ZouBeijing Language and Culture University

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Overview

Preclinical study demonstrates that a phosphatidylserine-presenting hydrogel accelerates diabetic wound closure in rats, suggesting a targeted biomaterial approach for chronic nonhealing wounds.

Key Points

  • Investigate whether presenting biomimetic phosphatidylserine signals via a hydrogel can rescue macrophage dysfunction through the CD300a receptor to accelerate diabetic wound healing.
  • Fabricated a photocrosslinkable hyaluronic acid methacryloyl (HAMA) hydrogel incorporating PEGylated RGD-grafted phosphatidylserine liposomes (PEG/RGD-PSLs).
  • Evaluated macrophage migration, M1-to-M2 phenotype switching, mitochondrial protection, and CD300a/MyD88/NF-κB signaling under diabetic-mimicking conditions with siRNA knockdown validation.
  • Tested in vivo regenerative efficacy following a single application of the bioactive hydrogel in a diabetic rat wound model.
  • PEG/RGD-PSLs significantly promoted macrophage migration, shifted polarization from M1 to M2, and protected mitochondrial integrity by suppressing oxidative stress.
  • Therapeutic actions operated via CD300a upregulation and downstream inhibition of the MyD88/NF-κB pathway; siRNA knockdown of CD300a completely abrogated these anti-inflammatory effects.
  • A single application of the bioactive hydrogel significantly accelerated wound closure, enhanced angiogenesis, improved organized collagen deposition, and established an M2-dominant immune microenvironment in diabetic rats.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a97e28dc562ede874ec6b0ehttps://doi.org/10.1002/adhm.71648
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