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March 19, 2026Bioactive MaterialsOpen Access

Glucose/ROS-responsive and redox-gated adaptive hydrogel dressing for accelerating diabetic wound repair via synergistic cGAS/STING pathway inhibition and oxidative stress alleviation

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Authors

XWX T WangYLYang LiuTNTianqi Nie

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Overview

Developed hydrogel dressing accelerates wound repair in diabetes by inhibiting inflammation and oxidative stress.

Key Points

  • This research aims to develop a hydrogel dressing that responds to glucose and reactive oxygen species to enhance diabetic wound healing.
  • Created a glucose/ROS-responsive hydrogel using dynamic crosslinking with chlorogenic acid and sodium alginate.
  • Incorporated phosphatidylserine-targeting liposomes to deliver a STING inhibitor to macrophages.
  • Evaluated the hydrogel in diabetic wound models for healing efficacy and inflammatory response.
  • Assessed key outcomes like cytokine levels, collagen content, and angiogenesis markers.
  • Achieved a 79.9% reduction in superoxide anion levels.
  • Enhanced angiogenesis with a 6.6-fold increase in CD31 and 7.3-fold increase in VEGF levels.
  • Collagen content improved significantly from 32.6% to 69.3%.
  • Demonstrated 89.7% wound recovery within 10 days and near-complete healing by 14 days.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69bb92d1496e729e62980653https://doi.org/10.1016/j.bioactmat.2026.03.025
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