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September 10, 2025Nature CommunicationsOpen Access

Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target

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Authors

LCLaura Llaó CidJWJkl WongIBIria Fernandez Botana

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Overview

Observational analysis identifies galectin-9 as an immunotherapy target in chronic lymphocytic leukemia, suggesting implications for treatment strategies.

Key Points

  • Galectin-9 inhibition reduced disease progression in a mouse model, indicating potential for immunotherapy advancement.
  • Accumulation of exhausted T cells in lymph nodes was notable, particularly regulatory T cells and CD8+ T cells.
  • Single-cell RNA sequencing and interactome studies underscore the complex immune landscape in chronic lymphocytic leukemia.
  • Galectin-9's correlation with poor survival in CLL highlights its role in immune evasion and suggests therapeutic relevance.

Cite This Study

Cid et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd2a54b1d3bfb60ee126https://doi.org/10.1038/s41467-025-61822-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrative multi-omics identifies regulatory and exhausted T cell types and novel immunotherapy targets in CLL lymph nodes2024
  2. 2TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target2021 · 31 citations
  3. 3Diffuse large B-cell lymphoma: the significance of CD8+ tumor-infiltrating lymphocytes exhaustion mediated by TIM3/Galectin-9 pathway2024 · 14 citations
  4. 4IL‑10 limits CLL progression by reprogramming T cell exhaustion and myeloid suppression2025
  5. 5Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia2024 · 6 citations