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September 10, 2025Scientific ReportsOpen Access

MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response

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Authors

ZWZhao-Feng WenAnhui Medical UniversityQHQi-Tang HuangAnhui Medical UniversityYWYangyang WangSouth China Agricultural University

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Implication

Investigating the impact of MCP-1 and CCR2 blockade on immune response and DLBCL progression.

Key Points

  • Blocking the MCP-1/CCR2 axis significantly hinders DLBCL tumor growth and improves immune response.
  • Prognostic markers MCP-1, CD68, and CD163 are expressed in patients with diffuse large B-cell lymphoma.
  • Macrophage polarization was mimicked in vitro, showing the important role of the MCP-1/CCR2 axis.
  • CCR2 antagonist intervention reduced monocyte recruitment, affecting macrophage function in tumors.

Cite This Study

Wen et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3254b1d3bfb60ee45ahttps://doi.org/10.1038/s41598-025-14527-6
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