Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood AdvancesOpen Access

Cutaneous diffuse large B-cell lymphoma induces a macrophage immunosuppressive phenotype through IL-10 secretion.

View Full Paper
Ask AI
Bookmark
Share

Authors

RPRémi PeanneVMValérie Le MorvanTBThibaut Blondy

Discussion

Loading...

Member takes

Overview

Analysis reveals macrophages enhance tumor cell proliferation and resist doxorubicin in PCDLBCL-LT, suggesting IL-10 is crucial.

Key Points

  • Tumor associated macrophages increase proliferation and drug resistance, underlining a critical role in lymphoma progression.
  • Macrophage polarization induced by lymphoma cells was linked to IL-10, showcasing how these cells alter immune response.
  • Observation of IL-10's impact was consistent across different patient-derived xenografts and THP-1 cell line experiments.
  • Findings may guide future treatment approaches focusing on macrophage interactions in the tumor microenvironment.

Cite This Study

Peanne et al. (2025) studied this question.

synapsesocial.com/papers/69401f0f2d562116f28fa1bdhttps://doi.org/10.1182/bloodadvances.2025016492
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cutaneous diffuse large B-cell lymphoma induce a macrophage immunosuppressive phenotype through IL-10 secretion2025
  2. 2MCP-1-CCR2-M2 macrophages axis contributes to diffuse large B-cell lymphoma progression and inhibits antitumor immune response2025 · 5 citations
  3. 3Myeloid landscape profiling identifies DLBCL-specific suppressive macrophages colocalized with blood endothelial cells2025 · 5 citations
  4. 4Abstract 2693: MicroRNA manipulation of macrophage polarization in DLBCL to augment antibody immunotherapy2024 · 1 citations
  5. 5Identification and validation of M2 macrophage-related differential genes in DLBCL2024