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September 10, 2025Emerging Microbes & InfectionsOpen Access

Two-threshold defined immune non-responders are associated with long-term morbidity in people with HIV: a prospective cohort study

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Authors

XLXiaorui LiLSLiqin SunYHYun He

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Overview

Prospective cohort study links immune non-responder status to increased risks of AIDS and non-AIDS diseases.

Key Points

  • Immune non-responder status is associated with significantly increased risks of AIDS-defining and non-AIDS-defining diseases.
  • In the low-threshold cohort, the adjusted hazard ratio for pneumocystis pneumonia was 10.10, based on long-term follow-up.
  • The study used Kaplan-Meier curves and Cox proportional hazards models to evaluate the association with long-term morbidity.
  • These findings suggest a need for better risk assessment to lower the disease burden in people with HIV.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3254b1d3bfb60ee4fchttps://doi.org/10.1080/22221751.2025.2539198
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