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September 10, 2025Discover OncologyOpen Access

Identifying key genes involved in HBV-related hepatocellular carcinoma: diagnose, prognosis, interaction and immune analysis

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Authors

YLYan LiSLS Y LiuJHJing Hu

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Overview

Analysis uncovers diagnostic and prognostic value of key genes in HBV-HCC, highlighting immune interactions.

Key Points

  • Identification of six hub genes reveals their significant role in HBV-HCC development and immune response.
  • Survival analysis indicated that NDC80, CDK1, and EZH2 are linked to shorter overall survival in HBV-HCC patients.
  • The study utilized GEO datasets for differential expression analysis, confirming key genes' diagnostic value.
  • Drug interactions with hub genes may offer promising therapeutic options for managing HBV-HCC.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3254b1d3bfb60ee539https://doi.org/10.1007/s12672-025-03320-6
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Also Consider

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  1. 1Identification of hub genes and pathways in hepatitis B virus‐associated hepatocellular carcinoma: A comprehensive in silico study2024 · 2 citations
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  4. 4Identification of most representative hub-genes for diagnosis, prognosis, and therapies of hepatocellular carcinoma2024 · 15 citations
  5. 5#RSAA2026 Identification of Key Hub Genes in Hepatocellular Carcinoma via Integrated Bioinformatics Analysis and Stringent PPI Network Filtering2026