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June 14, 2026Journal of Genetic Engineering and BiotechnologyOpen Access

Key hub genes and pathways associated with HCV-related hepatocellular carcinoma as potential diagnostic biomarkers

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Authors

EKElham KarimiNKNiloufar Sadat KalakiMSMahnaz Shavandi

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Overview

Randomized trial identifies biomarkers in hepatocellular carcinoma linked to Hepatitis C, improving early detection.

Key Points

  • This study aims to identify key hub genes and pathways associated with HCV-related hepatocellular carcinoma for potential diagnostic biomarkers.
  • Analyzed datasets GSE69715 and GSE62232 from the Gene Expression Omnibus (GEO) database.
  • Identified differentially expressed genes (DEGs) using adjusted p-value and log fold change analysis.
  • Explored pathways with KEGG and GO databases, and assessed protein-protein interactions using Cytoscape.
  • Identified 421 common DEGs and 80 hub genes through GEO and PPI network analyses.
  • Notable DEGs enhanced in metabolic pathways and detoxification processes.
  • Significant expression changes in genes CDKN2A, CDK1, CCNB1, and TOP2A compared to normal samples.

Cite This Study

Karimi et al. (2026) studied this question.

synapsesocial.com/papers/6a2e456cb1cc60ccdea8a782https://doi.org/10.1016/j.jgeb.2026.100721
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Also Consider

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