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September 10, 2025S S Korsakov Journal of Neurology and Psychiatry

Effect of urolithin A on production of interleukins 6 and 10 by immune cells from patients with MS and healthy donors

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Authors

AKA. D. KukushkinaVRVladimir RogovskiiАBА. N. Boyko

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Overview

Observational analysis demonstrated Urolithin A increases IL-10 and decreases IL-6 production in MS patients, implying potential therapeutic effects.

Key Points

  • Urolithin A enhanced IL-10 production by about 28% in PBMCs from both MS patients and healthy donors, indicating its efficacy.
  • The baseline and lipopolysaccharide-stimulated IL-6 production in MS patients was higher than in healthy donors, pointing to an immune response difference.
  • Utilizing enzyme immunoassay, the study evaluated the effects of urolithin A on cytokine production from PBMCs and macrophages.
  • Given its immunotropic effects, urolithin A may pave the way for future clinical studies targeting multiple sclerosis.

Cite This Study

Kukushkina et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3b54b1d3bfb60ee5edhttps://doi.org/10.17116/jnevro202512507284
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Also Consider

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  1. 1Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A2024 · 1 citations
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  5. 5Effects of urolithin A on adipogenesis, lipogenesis, and lipolysis in 3T3-L1 adipocytes: an experimental study2026