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September 10, 2025

Role and mechanism of YAP1 in pan-cancer

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Observational analysis reveals Yap1's potential as a biomarker in pan-cancer, indicating significant mutation frequencies.

Yap1 is significantly lower in tumor tissues compared to controls, highlighting its potential diagnostic role.
Yap1 serves as a prognostic predictor in PAAD and KIRC, and is linked to immune infiltration.
Yap1 exhibits a high mutation frequency across various cancer types, which could inform targeted therapy.
Phosphorylation sites, especially S276 in Yap1, are likely critical for its interacting proteins and functions.

Yufan Xu (2025) studied this question.

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