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September 10, 2025MedicinaOpen Access

The Impact of Yes-Associated Protein 1 (YAP1) Expression Patterns in Locally Advanced Breast Cancer: Associations with Pathological Response and Tumor Features

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OEOsman Erinç SASabin Göktaş Aydın TETaşkın Erkinüresin

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Overview

Observational analysis highlights YAP1's significant role in predicting pathological response in breast cancer, indicating its potential therapeutic relevance.

Key Points

YAP1 expression significantly predicts axillary pathological complete response, showing 77.8% pCR in YAP1-positive patients.
The relationship between YAP1 expression and tumor subtype is significant, particularly higher in HER-2-positive tumors at 55.6%.
Post-treatment, nuclear YAP1 expression decreased significantly, while cytoplasmic staining increased, suggesting a localization shift.
Higher Ki-67 values are significantly associated with positive YAP1 expression, suggesting YAP1's role in tumor proliferation.

Cite This Study

Erinç et al. (2025) studied this question.

synapsesocial.com/papers/68c1a3f954b1d3bfb60de0da https://doi.org/10.3390/medicina61071297

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September 10, 2025MedicinaOpen Access

The Impact of Yes-Associated Protein 1 (YAP1) Expression Patterns in Locally Advanced Breast Cancer: Associations with Pathological Response and Tumor Features

View Full Paper

Ask AI

Bookmark

Authors

OEOsman Erinç SASabin Göktaş Aydın TETaşkın Erkinüresin

Discussion

Member takes

Overview

Observational analysis highlights YAP1's significant role in predicting pathological response in breast cancer, indicating its potential therapeutic relevance.

Key Points

YAP1 expression significantly predicts axillary pathological complete response, showing 77.8% pCR in YAP1-positive patients.
The relationship between YAP1 expression and tumor subtype is significant, particularly higher in HER-2-positive tumors at 55.6%.
Post-treatment, nuclear YAP1 expression decreased significantly, while cytoplasmic staining increased, suggesting a localization shift.
Higher Ki-67 values are significantly associated with positive YAP1 expression, suggesting YAP1's role in tumor proliferation.

Cite This Study

Erinç et al. (2025) studied this question.

synapsesocial.com/papers/68c1a3f954b1d3bfb60de0da https://doi.org/10.3390/medicina61071297

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