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December 4, 2025MedicinaOpen Access

Expression of Core Hippo Pathway Proteins in Cervical Cancer and Their Association with Clinicopathologic Parameters

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Authors

MKMin Hye KimJYJuseok YangDSdae-hyun Song

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Overview

Observational analysis shows Hippo pathway dysregulation correlates with tumor size in cervical cancer, suggesting therapeutic potential for YAP.

Key Points

  • YAP and p-YAP overexpression correlates with larger tumor size and advanced stage in cervical cancer.
  • YAP expressed in 71.8% of tumors and p-YAP in 62.6%, with significant associations to tumor size (p = 0.013).
  • Immunohistochemical staining analyzed key proteins in cancer specimens from the Gyeongsang National University Hospital.
  • YAP functional suppression impairs cell migration, highlighting its role as a prognostic biomarker.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3993https://doi.org/10.3390/medicina61122134
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancer2024 · 25 citations
  2. 2The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression2015 · 288 citations
  3. 3The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer2022 · 339 citations
  4. 4The Hippo Pathway Effectors YAP/TAZ-TEAD Oncoproteins as Emerging Therapeutic Targets in the Tumor Microenvironment2023 · 85 citations
  5. 5SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK2017 · 133 citations