Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Anticancer ResearchOpen Access

The Significance of Phosphorylated Yes-associated Protein (YAP) (Ser 127) Expression in Oral Squamous Cell Carcinoma

View Full Paper
Ask AI
Bookmark
Share

Authors

YAYusuke AmanoDMDaisuke MatsubaraAKAtsushi Kihara

Discussion

Loading...

Member takes

Overview

This study finds that phosphorylated YAP expression relates to differentiation in oral squamous cell carcinoma, suggesting potential prognostic significance.

Key Points

  • High phosphorylated YAP expression indicates a correlation with aggressive characteristics of oral squamous cell carcinoma.
  • Low pYAP expression was found in oral epithelial dysplasia, carcinoma in situ, and oral squamous cell carcinoma.
  • The expression of low levels of YAP was significantly more common in well-differentiated tumors compared to poorly differentiated tumors.
  • Elevated pYAP expression may serve as a prognostic indicator for oral squamous cell carcinoma during the invasive stage.

Cite This Study

Amano et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef02b87ece8dc9574c1https://doi.org/10.21873/anticanres.17743
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The significance of Hippo pathway protein expression in oral squamous cell carcinoma2024 · 3 citations
  2. 2Role of Yes-associated protein [YAP]- A Key Hippo Component in the Onset and Progression of Oral Squamous Cell Carcinoma2025
  3. 3Overexpression of yes‐associated protein contributes to progression and poor prognosis of non‐small‐cell lung cancer2010 · 349 citations
  4. 4The Impact of Yes-Associated Protein 1 (YAP1) Expression Patterns in Locally Advanced Breast Cancer: Associations with Pathological Response and Tumor Features2025 · 1 citations
  5. 5Expression of Core Hippo Pathway Proteins in Cervical Cancer and Their Association with Clinicopathologic Parameters2025