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September 10, 2025Journal of Stem Cell Research and Tissue EngineeringOpen Access

Decoding Yap-Driven Malignant Reprogramming in Oral Epithelial Stem Cells Through Single-Cell Analysis

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Authors

HMHanisa Aulia MaharaniIPIndah Salsabila Febriana PutriHHarmin

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Overview

Literature review highlights YAP’s impact on cancer stem-like cells in OSCC, suggesting therapeutic targets.

Key Points

  • YAP activation induces stemness-related genes in oral epithelial cells, promoting cancer development.
  • Single-cell RNA sequencing shows dynamic cell states in oral squamous cell carcinoma (OSCC) linked to YAP.
  • The Hippo pathway effector YAP shapes the tumor microenvironment, aiding in cancer progression.
  • Inhibiting YAP targets may reduce proliferation and stemness, highlighting a potential intervention point.

Cite This Study

Maharani et al. (2025) studied this question.

synapsesocial.com/papers/68c1a78154b1d3bfb60e0ff6https://doi.org/10.20473/jscrte.v9i1.73558
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 1707: YAP-driven epigenetic reprogramming in head and neck cancer2024
  2. 2Role of Yes-associated protein [YAP]- A Key Hippo Component in the Onset and Progression of Oral Squamous Cell Carcinoma2025
  3. 3YAP as a therapeutic target in esophageal squamous cell carcinoma: insights and strategies2025
  4. 4Multidimensional Regulatory Network of <i>YAP1</i> Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review2026
  5. 5The Significance of Phosphorylated Yes-associated Protein (YAP) (Ser 127) Expression in Oral Squamous Cell Carcinoma2025 · 1 citations