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August 25, 2025CancersOpen Access

Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion

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Authors

XHXi HuangMZMingyan ZhangAPAlexander D. Pearce

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Overview

This research finds YAP activation enhances tumor metastasis and immune evasion in cancer cells, suggesting new therapeutic approaches.

Key Points

  • YAP activation promotes multiple malignant traits in cancer, enhancing tumor progression and immune evasion.
  • Pharmacological inhibition of YAP reduces EMT-driven cell migration and resistance to apoptosis, highlighting its role in cancer.
  • The study shows that ZEB transcription factors repress WWC1, impairing Hippo signaling and causing YAP activation.
  • Targeting YAP could improve anti-PD-1 immunotherapy efficacy by addressing EMT-related malignant properties.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68af63e9ad7bf08b1eae489dhttps://doi.org/10.3390/cancers17172767
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion2025 · 1 citations
  2. 2ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types2016 · 303 citations
  3. 3Linking EMT Dynamics to Cellular Plasticity: YAP/TAZ as Central Regulators Across Physiological and Pathological States2026
  4. 4Extracellular matrix reprogramming by the YAP/TAZ– TGF-ß2 axis drives immune exclusion in cholangiocarcinoma models2026 · 1 citations
  5. 5Multidimensional Regulatory Network of <i>YAP1</i> Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review2026