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July 21, 2025Open Access

Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion

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Authors

XHXi HuangMZMingyan ZhangAPA. Pearce

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Overview

Experimental findings reveal that EMT activates YAP via WWC1 repression, suggesting new treatments against immune evasion in cancer.

Key Points

  • MAIN FINDING: EMT activates YAP through the repression of WWC1, driving cancer cell progression and immune evasion.
  • KEY EVIDENCE: Inhibition of YAP significantly reduced cell migration, invasion, and resistance to apoptosis.
  • APPROACH: The study examined the molecular pathways linking EMT and YAP in cancer cells through biochemical assays.
  • SIGNIFICANCE: Targeting YAP could enhance anti-PD-1 immunotherapy effectiveness, representing a promising therapeutic avenue.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/689a060ee6551bb0af8cd130https://doi.org/10.20944/preprints202507.1544.v1
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