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July 26, 2026GenesOpen Access

Linking EMT Dynamics to Cellular Plasticity: YAP/TAZ as Central Regulators Across Physiological and Pathological States

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Authors

LALaura AmiconeCCCarla CicchiniFPFabio Petti

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Overview

Review highlights YAP/TAZ's role in regulating EMT dynamics in physiological and pathological conditions, indicating therapeutic potential.

Key Points

  • The aim is to explore how YAP and TAZ regulate EMT dynamics and cellular plasticity across different states.
  • Review of existing literature on YAP/TAZ and EMT signaling pathways.
  • Analysis of YAP/TAZ's interactions with mechanical, biochemical, and metabolic signals.
  • Discussion of the implications of YAP/TAZ in physiological processes like development and pathology such as cancer.
  • YAP/TAZ serve as a central hub integrating signals to control cell fate reprogramming.
  • Interconnected feedback and feed-forward loops within the YAP/TAZ-EMT axis stabilize cellular plasticity.
  • Understanding YAP/TAZ mechanisms can aid in developing therapies for cancer and fibrosis.

Cite This Study

Amicone et al. (2026) studied this question.

synapsesocial.com/papers/6a65a7b4d3aea3239cd785achttps://doi.org/10.3390/genes17080851
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Also Consider

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  1. 1p300 Acetyltransferase Is a Cytoplasm‐to‐Nucleus Shuttle for SMAD2/3 and TAZ Nuclear Transport in Transforming Growth Factor β–Stimulated Hepatic Stellate Cells2019 · 93 citations
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  3. 3Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis2018 · 71 citations
  4. 4YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury2018 · 221 citations