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September 20, 2025Oral Sciences ReportsOpen Access

Role of Yes-associated protein YAP- A Key Hippo Component in the Onset and Progression of Oral Squamous Cell Carcinoma

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Authors

NIN IndumathiNGNandhini GunasekaranKPK Poonguzhalnalli

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Overview

This review highlights YAP's role in regulating tumorigenesis in oral squamous cell carcinoma, suggesting it as a potential therapeutic target.

Key Points

  • YAP plays a crucial role in the onset and progression of oral squamous cell carcinoma, indicating its potential as a therapeutic target.
  • Recent studies show that YAP dysregulation is linked to tumor growth and metastasis in patients with oral squamous cell carcinoma.
  • A comprehensive literature search identified key mechanisms by which YAP influences cancerogenesis in oral cancer.
  • Understanding YAP's functions can provide insights for developing targeted therapies against oral squamous cell carcinoma.

Cite This Study

Indumathi et al. (2025) studied this question.

synapsesocial.com/papers/68d46aae31b076d99fa67805https://doi.org/10.12982/osr.2025.055
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Regulation and Function of Hippo/ <scp>YAP</scp> Pathway in Cancer2026 · 5 citations
  2. 2The Significance of Phosphorylated Yes-associated Protein (YAP) (Ser 127) Expression in Oral Squamous Cell Carcinoma2025 · 1 citations
  3. 3The Noncanonical Role of Hippo Signaling in Cancer2026
  4. 4YAP as a therapeutic target in esophageal squamous cell carcinoma: insights and strategies2025
  5. 5DECODING YAP-DRIVEN MALIGNANT REPROGRAMMING IN ORAL EPITHELIAL STEM CELLS THROUGH SINGLE-CELL ANALYSIS2025