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July 23, 2025Annals of MedicineOpen Access

YAP as a therapeutic target in esophageal squamous cell carcinoma: insights and strategies

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Authors

WWWeilong WangSouthwest University of Science and TechnologyTCTingmin ChangHealth Commission of Anhui ProvinceLWLingchao WangFirst Affiliated Hospital of Xinxiang Medical University

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Overview

Literature review reveals YAP as a therapeutic target for esophageal squamous cell carcinoma, suggesting potential for improved treatment outcomes.

Key Points

  • YAP is an oncogene and tumor suppressor, making it crucial for understanding cancer mechanisms in ESCC.
  • The review highlights YAP's regulatory mechanisms, including post-translational modifications that affect its function in tumors.
  • High YAP expression in ESCC correlates with poor patient prognosis and aggressive tumor behavior.
  • YAP-targeted therapies are limited clinically, indicating a need for further research to develop effective treatments.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdaefhttps://doi.org/10.1080/07853890.2025.2536200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multidimensional Regulatory Network of <i>YAP1</i> Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review2026
  2. 2Overexpression of YAP confers radioresistance to esophageal cancer by altering the tumor microenvironment2024 · 2 citations
  3. 3Role of Yes-associated protein [YAP]- A Key Hippo Component in the Onset and Progression of Oral Squamous Cell Carcinoma2025
  4. 4The potential relationship between YAP and PCNP in esophageal carcinoma and its influence on carcinogenesis2025
  5. 5DECODING YAP-DRIVEN MALIGNANT REPROGRAMMING IN ORAL EPITHELIAL STEM CELLS THROUGH SINGLE-CELL ANALYSIS2025