Clinicopathological Study of Soft Tissue Tumors and Immunohistochemical Analysis

A BSTRACT Background: Soft-tissue tumors (STTs) are a rare and heterogeneous group of tumors, arising in connective tissues, mesenchymal in origin, and exhibit benign, intermediate or malignant behavior. Aims: This study was undertaken to assess the clinicopathological profile of the patients with STTs with the help of immunohistochemistry (IHC) markers as and when required. Materials and Methods: The present study was carried out on 123 cases of STTs for the study period of 18 months. Clinicopathological parameters were assessed, and IHC markers were used judiciously for confirmation of the diagnosis wherever required. Results: The mean age of the patients was 33.72 years where it was 41.38 years in case of malignancies. Mostly, STTs were located in the head and neck region (31.7%), but it was lower limb (37.5%) in malignant cases. The mean size of the soft tissue tumor was 3.7 cm and malignant tumor was 7.5 cm. The present study revealed 81.3% of benign tumors and 78.9% tumors in superficial planes. Majority (29.3%) of the STTs were vascular in origin. Conclusion: Most of the STTs are benign in nature. Age and size of malignant STTs are more than those of benign STTs. IHC markers are essential especially in the diagnosis of malignant tumors.