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September 10, 2025Nephrology and Dialysis

Membranous nephropathy in patients with anti-myeloperoxidase antibody associated systemic vasculitis: a report of two cases

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Authors

NBN. BulanovSechenov UniversityDSD. V. StarikovMoscow Research and Clinical Center for NeuropsychiatryESE. S. StolyarevichMoscow State University of Medicine and Dentistry

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Implication

This report discusses the rare coexistence of membranous nephropathy and glomerulonephritis in patients with MPO-ANCA systemic vasculitis.

Key Points

  • Both patients with ANCA-associated vasculitis displayed unique presentations of membranous nephropathy.
  • Patient 1 experienced multiple complications, including nephrotic syndrome and infections leading to a lethal outcome.
  • Kidney biopsies confirmed the presence of membranous nephropathy alongside other glomerular lesions.
  • Immunosuppressive treatment proved challenging, highlighting the complexity of managing MPO-ANCA-associated diseases.

Cite This Study

Bulanov et al. (2025) studied this question.

synapsesocial.com/papers/68c1c22554b1d3bfb60ef37fhttps://doi.org/10.28996/2618-9801-2025-2-191-200
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myeloperoxidase-Associated Membranous Nephropathy in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis2024 · 9 citations
  2. 2New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system.1987 · 235 citations
  3. 3Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis2013 · 259 citations
  4. 42012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides2012 · 6,690 citations