Observational study reveals myeloperoxidase-related membranous nephropathy in ANCA-associated glomerulonephritis, suggesting diagnosis complexity.
Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) (ANCA GN) is characterized as a pauci-immune type of crescentic GN. However, several studies have demonstrated the presence of membranous nephropathy (MN) as a rare concomitant pattern of ANCA GN. A granular pattern of myeloperoxidase (MPO) and immunoglobulin G (IgG) deposition along the glomerular basement membrane (GBM) was also observed in patients with MPO-ANCA GN and MN. Furthermore, MPO can be detected within subepithelial electron-dense deposits (EDD) in patients with MPO-ANCA GN accompanied by MN lesions.
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Tominaga et al. (2026) studied this question.
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