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Harnessing intratumoral microbiota: new horizons in immune microenvironment and immunotherapy

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Intratumoral microbiota reshape the immune landscape, affecting cancer progression and treatment efficacy.
These microbes influence cytokines like IFN-γ and TNF-α, showing diverse roles across various cancer types.
Innovative strategies leveraging engineered bacteria and oncolytic viruses may enhance cancer treatment outcomes.
Understanding microbial-host interactions could lead to advancements in microbiota-based cancer diagnostics.

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This review uncovers how intratumoral microbiota impact immune responses in solid tumors, suggesting new immunotherapy strategies.

Zhang et al. (2025) studied this question.

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