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This review aims to elucidate the role of intratumoral microorganisms in cancer dynamics and therapeutic effectiveness.

May 7, 2026MedCommOpen Access

Intratumoral Microorganisms in Tumors: Current Understanding and Emerging Therapeutic Strategies

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This review aims to elucidate the role of intratumoral microorganisms in cancer dynamics and therapeutic effectiveness.
Examined microbial diversity and associations with different tumor types.
Analyzed mechanisms such as immune modulation and metabolic reprogramming.
Discussed clinical implications including biomarker discovery and microbiome-targeted therapies.
Identified multiple mechanisms through which intratumoral microbiota influence tumor progression.
Highlighted the context-dependent nature of microbial contributions to cancer.
Proposed frameworks for integrating microbiome data into precision oncology strategies.

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Review discusses intratumoral microbiota's role in tumor behavior and therapeutic responses, suggesting pathways for precision oncology.

Zhang et al. (2026) studied this question.

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