Extracellular vesicles from the follicular fluid of competent oocytes improve blastocyst yields when supplemented during simulated physiological oocyte maturation in cattle
Observational analysis showed increased blastocyst rates with extracellular vesicles from competent oocytes in cattle, suggesting their vital role in oocyte maturation.
Key Points
EVs from competent oocytes improved blastocyst rates during maturation, indicating their developmental benefits.
Only EVs from competent follicles enhanced blastocyst yields significantly at 10 million EVs per mL, supporting their efficacy.
Analysis revealed miR-143 did not enhance development, yet its inhibition led to reduced blastocyst rates, suggesting key regulatory roles.
Findings highlight the potential of extracellular vesicles in reproductive technologies, enhancing assisted reproductive outcomes.