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Synapse
May 1, 2026Open Access

Treatment of human oocytes with extracellular vesicles from follicular fluid during rescue in vitro maturation enhances maturation rates and modulates oocyte proteome and ultrastructure

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Authors

SMSofia MakievaMSMara D Saenz-de-JuanoCACarmen AlmiñanaUniversity Hospital of Zurich

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Overview

Randomized trial finds enhanced oocyte maturation with follicular fluid-derived extracellular vesicles, indicating potential clinical applications.

Key Points

  • To investigate whether follicular fluid-derived extracellular vesicles can improve human oocyte maturation rates during in vitro maturation.
  • Recruitment of 83 women undergoing transvaginal oocyte retrieval after controlled ovarian stimulation.
  • Isolated extracellular vesicles from follicular fluid by ultracentrifugation; assessed oocyte uptake via confocal microscopy.
  • Compared maturation rates and proteomic profiles of oocytes cultured with and without MII-ffEVs.
  • Supplementation with MII-ffEVs increased maturation rates to 77.8% compared to 55% in the control group (P=0.0372).
  • Identified 1340 proteins in ffEVs; significant enrichment of proteins like Hyaluronan Synthase 1 in supplemented oocytes.
  • Observed alterations in organelle distribution, specifically in the endoplasmic reticulum and ER-mitochondria complexes.

Cite This Study

Makieva et al. (2026) studied this question.

synapsesocial.com/papers/69f44488967e944ac556786ahttps://doi.org/10.5167/uzh-433875
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of human oocytes with extracellular vesicles from follicular fluid during rescue <i>in vitro</i> maturation enhances maturation rates and modulates oocyte proteome and ultrastructure2026
  2. 2O-005 The in vitro maturation rate of human oocytes is enhanced following uptake of extracellular vesicles derived from mature follicles2024 · 1 citations
  3. 3Extracellular vesicles from the follicular fluid of competent oocytes improve blastocyst yields when supplemented during simulated physiological oocyte maturation in cattle2025 · 5 citations
  4. 4Follicular fluid-derived small extracellular vesicles during individual in vitro maturation improve blastocyst development2025
  5. 5P-795 Robust and simple in vitro maturation of ovarian tissue oocytes2024