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September 10, 2025Cell Death and DiseaseOpen Access

Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation

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Authors

HSHans Felix StaehleCKChristoph KoellererASAnne Marie Staehle

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Overview

Investigative analysis reveals LSD1's non-enzymatic role in myeloid cell differentiation, highlighting GFI1 dependence.

Key Points

  • Myeloid differentiation relies on LSD1's scaffolding function, not its enzymatic activities.
  • Loss of LSD1 results in diminished GFI1 binding, halting myeloid differentiation at an immature stage.
  • Prtn3 is identified as crucial for stem cell expansion and myeloid maturation impacted by LSD1 loss.
  • Understanding LSD1's functions could inform therapeutic strategies in hematological disorders.

Cite This Study

Staehle et al. (2025) studied this question.

synapsesocial.com/papers/68c1c23554b1d3bfb60efad1https://doi.org/10.1038/s41419-025-07951-z
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