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September 10, 2025Pharmaceutical ResearchOpen Access

Pharmacokinetic Assessment of Drug Efflux from Erythrocytes Loaded with Corticosteroid Esters

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Observational study characterized pharmacokinetics of erythrocyte-loaded corticosteroid prodrugs, suggesting bioavailability in humans and animals.

Markedly prolonged plasma concentrations of dexamethasone and betamethasone indicate effective drug efflux.
A three-phase pharmacokinetic model revealed 0.72 fraction of dexamethasone released within 1 hour in humans.
The study utilized a pharmacokinetic model on corticosteroid prodrugs in both rabbits and rats, demonstrating similar results.
Findings suggest that erythrocytes can serve as effective carriers for prolonged drug delivery of corticosteroids.

Jusko et al. (2025) studied this question.

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Observational study characterized pharmacokinetics of erythrocyte-loaded corticosteroid prodrugs, suggesting bioavailability in humans and animals.